Studies of linear ubiquitin and different modes of cell death induction by TNF family members in aetiology and treatment of autoimmunity

Professor Walczak's work examines the modulation of cell death in the context of experimental and clinical autoimmunity. With this award he will investigate the control of different forms of cell death and the determinants of whether cell death leads to inflammation or autoimmunity, through an analysis of the different cell death modalities induced by members of the TNF cytokine family and the role linear ubiquitination plays in determining this.