Spine-specific targeting of ion channels in striatal neurons

The focus of Andrew's Fellowship is to determine how an individual neuron distinguishes information from different brain regions at the molecular and cellular level, to allow for input-specific signalling in the nervous system. He is currently investigating this question with Dr Adam Carter at New York University, using a novel combination of two-photon microscopy, fluorescent calcium imaging and optogenetics, to identify and characterise inputs from different brain regions. He will then work with Professor Mark Farrant at UCL to dissect the molecular determinants of these different inputs and create a model of input specificity.