Single molecule insights into nuclear mechanotransduction

Cells are continuously exposed to mechanical perturbations from the environment. While some are sensed and remain at the cell surface, others can travel long distances inside the cell to reach the nucleus, where most cell fate decisions are made. Mechanical forces determine many cell functions, for example in modulating adhesion or growth, and are also related to cardiovascular pathologies or cancer. However, the mechanisms by which mechanical forces travel across the cell and initiate biochemical changes inside the nucleus are poorly understood.  

Many of the scientific methods commonly used in molecular and cell biology cannot apply and monitor the effects of forces. My research will combine new techniques to apply controlled forces to individual proteins and cells, and study how these forces are transmitted to the cell nucleus and affect cell behaviour.