Ribosomal frame-shifting and read-through in virus gene expression


  • Dr Nerea Irigoyen

    University of Cambridge

Project summary

Nerea is working in Dr Ian Brierley's laboratory in the Division of Virology, University of Cambridge, investigating the implication of frame-shifting and read-through in retrovirus replication, which can lead to a potential selection of antiviral agents that would be able to target these steps. She has planned to spend time in two other laboratories – those of Dr Robert Gilbert at the Structural Biology Institute in Oxford (cryo-EM reconstruction of read-through pseudoknot-stalled ribosome complexes and isothermal titration calorimetry of morpholino oligonucleotide-pseudoknot complexes) and Professor Stuart Siddell in Bristol (frame-shifting in coronavirus).