Regulatory dynamics of vertebrate neural tube development
Year of award: 2012
Grantholders
Dr James Briscoe
The Francis Crick Institute
Dr Karen Page
Department of Mathematics
Project summary
This joint Investigator Award will draw on the complementary expertise of Dr Briscoe and Dr Page in the areas of developmental biology and mathematics, respectively. The overall goal of their work is to understand the mechanisms of pattern formation in developing tissues, using the vertebrate neural tube as a model. The researchers will build on their recent studies in the neural tube, which have shed light on how patterns of gene expression are formed in response to external cues, by attempting to reconstitute neural tube development in silico and in vitro.