Regulation of Met1-linked ubiquitin and its impact on immune function

Infections by microbes, such as bacteria and viruses, are a constant threat to human health and we rely on effective, balanced, immune responses to keep us healthy. Genetic defects or pathogens that alter how the immune system is activated, can cause severe and potentially life-threatening conditions such as inflammatory bowel disease and sepsis. It is important to understand the mechanisms in cells that dictate how the immune system works and reacts to infection. 

I will build on discoveries made in my research group that have advanced our understanding of how cells precisely control the immune responses to life-threatening infections. 

My discoveries will help the development of novel drugs to improve treatment of immune-driven disease.