Putting genomic surveillance at the heart of viral epidemic response
Year of award: 2017
Grantholders
Prof Andrew Rambaut
University of Edinburgh
Prof Marc Suchard
University of California, Los Angeles
Prof Philippe Lemey
University of Leuven
Prof Ian Goodfellow
University of Cambridge
Prof Christopher Fraser
University of Oxford
Prof Nicholas Loman
University of Birmingham
Dr Trevor Bedford
Fred Hutchinson Cancer Research Centre
Project summary
In recent outbreaks of viral disease such as Ebola and Middle East respiratory syndrome coronavirus (MERS-CoV), molecular sequencing of the viral pathogen has revealed critical insights into the evolution and transmission of the disease. This suggests into the potential value of this approach when attempting to control viral outbreaks. However, the scale and impact of new DNA technologies has largely been stunted, in part due to the complexities and logistics of shipping samples for sequencing and resulting delays in the production of the sequence data meaning that the inferences have limited usefulness for the response efforts.
We aim to produce a cheap, mobile, virus sequencing system, supported by statistically rigorous analysis frameworks along with information sharing platforms to prepare for the next outbreak and ensure that viral genome sequencing can have a greater impact on the public health response.