Protein structures in the context of time and space by mass spectrometry

Juri wonders if protein structures could be studied in the native context of the proteins. He uses cross-linking/mass spectrometry (CLMS), an approach his lab helped to pioneer during his previous Fellowship. CLMS already forms part of an integrated structural biology approach. Now, Juri hypothesises that CLMS can generate structural insights into currently difficult targets of structural biology. In particular, he investigates MeCP2, a protein with important biological functions in the context of chromatin, but whose structure cannot be determined in isolation.