Preclinical Toxicology Testing and IND application for a Novel Cholera Conjugate Vaccine

Cholera is a disease of inequity that continues to disproportionately affect the world's poorest and most vulnerable people. An oral cholera vaccine (OCV) is available and in use around the world, but it has lower efficacy in young children than in adults and a relatively short duration of protection necessitating re-vaccination every few years. We are developing a new conjugate vaccine that offers the promise of improved efficacy in all age groups, including those less than 5 years, and an extended duration of protection, thus reducing the requirements for repetitive vaccination to sustain population immunity. It can be implemented in place of OCV or as a complementary tool to prevent or limit outbreaks in high risk settings, and build enduring population immunity that will cost-effectively control cholera over the decades required to build definitive public health capacities in at risk countries.