Non-coding RNA (ncRNA) function in genome regulation and cell maintenance

Genome sequences often contain large non-coding regions, also known as 'gene deserts', which produce ncRNAs. Genetic variations associated with complex disorders frequently map to these areas, raising important questions about how much genetic information is transacted by ncRNAs. Professor Bähler will investigate the role of such ncRNAs in cellular function and ageing, using fission yeast (Schizosaccharomyces pombe) as a model system. He aims to explore the ability of these ncRNAs to tune gene expression, mediate gene-environment interactions, and generate phenotypic variation and plasticity.