Non-Invasive Modulation of Network Dynamics and Cognition

Translation from neuroscience knowledge acquired in animal models to human subjects is a major current problem for brain disorders. As a result, many promising findings from animal work fail to transform into treatment that we can use in the clinic. Here, I aim to take a brain networks approach to bridge this cross-species gap. Using state-of-the-art technological advances, I will examine specific brain circuits concurrently in both rodent and human subjects, while using a unitary analysis of the acquired data. Using this information, I will then perform non-invasive transcranial stimulation to influence the brain circuits and ultimately behavior. Finally, I will use a so-called closed-loop approach, where stimulation is determined by, as well as precisely timed to, simultaneously measured signals from the brain. Together, this approach could yield cheap, non-invasive and personalized approaches to altering brain circuits and behavior, with potential applications across a broad range of brain disorders.