Molecular mechanisms of transcriptional activation

Alan is a structural biologist interested in the fundamental mechanisms of gene transcription and how those mechanisms are used to control mRNA expression in eukaryotes. His group is based at the joint Institute of Structural and Molecular Biology at UCL and Birkbeck, and will combine a variety of structural, biochemical, biophysical and genetic methods to dissect and study the very large macromolecular complexes that mediate transcriptional activation. Alan's goal is to understand how these complexes act as focal points for transcriptional regulation.