Molecular basis of inheritable DNA lesions on genome transformation

Chris is a cell biologist whose group is based in the MRC Genome Damage and Stability Centre at the University of Sussex. His research focuses on understanding how genome integrity is maintained and restored under replication stress. Replication stress not only causes DNA damage during replication but also interferes with the timely completion of replication, which may result in the transmission of damaged genetic material into offspring cells. His main goal is to elucidate the mechanism(s) of genome rearrangements caused by replication stress induced DNA lesions, and ultimately develop preventative medicine and targeting therapy for cancers.