In vitro reconstitution of spindle bipolarity

During her Fellowship, Johanna will use the powerful combination of biochemistry and microscopy to elucidate the mechanics of chromosome segregation and spindle function. She will be based in the lab of Dr Thomas Surrey (London Research Institute, CRUK), collaborating with Professor Rebecca Heald and Professor Daniel Fletcher (University of California, Berkeley) and Dr François Nédélec (European Molecular Biology Laboratory, Heidelberg) to use novel in vitro reconstitution approaches to define the basic rules of bipolar spindle assembly.