Identification of atypical ubiquitylation and its role in inflammatory signalling

Year of award: 2013


  • Prof Mads Gyrd-Hansen

    University of Oxford

Project summary

Mads is a molecular biologist based at the Ludwig Institute for Cancer Research, University of Oxford. Mads studies the molecular mechanisms governing proinflammatory signalling during innate immune responses, with particular focus on bacteria-sensing pattern recognition receptors (PRRs). Through this, he aims to uncover the molecular switches that on one hand protect against invading pathogens but that also contribute to chronic inflammation and cancer. His current work focuses on delineating how the establishment and regulation of ubiquitin modifications control a cell’s proinflammatory response to PRR stimulation, with a particular focus on the signalling properties of individual ubiquitin linkage types.