Human adaptation to changing diet and infectious disease loads, from the origins of agriculture to present

Human diets have been changed by cultural, demographic and ecological changes over the past 10,000 years. While many methods and studies have been aimed at detecting recent natural selection, none can be as sensitive as the direct comparison of allele frequencies at different time points in continuous human populations. Furthermore, this approach is currently the only means of assessing temporal heterogeneity in natural selection. Archaeological and historical data are central to assessing the impact of key transitions of diet in this project.