How filopodia form

The ability of cells to sense their environment and move towards stimuli underlies embryonic development and the origin of multicellular life. Finger-like actin-rich protrusions, known as filopodia, are ubiquitous organelles of cell sensing and migration that are also involved in cell connectivity and tissue architecture. 

We will use biochemical and microscopic methods to understand the molecular mechanisms upon which filopodia carry out their functions. Using a unique cell-free system where filopodia-like structures can be generated, we will identify key filopodia proteins and regulators, and aim to reconstitute these structures from known purified components. In a cellular context, we will explore how membrane and actin dynamics give rise to filopodia in neurons in particular places and times. 

Unravelling the fundamental mechanisms of filopodial dynamics will lead to a wider understanding of the myriad ways filopodia function in biology.