Forensic epidemiology and impact of substandard and falsified antimicrobials on public health
Year of award: 2021
Grantholders
Prof Paul Newton
University of Oxford, United Kingdom
Prof Federico Varese
University of Oxford, United Kingdom
Prof Rob Ogden
University of Edinburgh, United Kingdom
Prof Heather Hamill
University of Oxford, United Kingdom
Dr Clark Freifeld
LexiGraph, United States
Dr Luana Bontempo
Edmund Mach Foundation, Italy
Prof Ben Cooper
University of Oxford, United Kingdom
Project summary
Poor quality medicines (falsified, aka counterfeit, and substandard) for treating infections are a massive underappreciated global health challenge in great need of innovative research informing interventions. We will build on our collective pioneering research, constructing an innovative, multidisciplinary research collaboration, improving our understanding and informing global policy and action. Leading specialists investigating illegal wildlife trade, forensics, social network analysis and modelling, will work together to address two main aims:
1. How can innovative forensic techniques be used to identify falsified antimicrobial sources and trade routes?
We will compare signatures of trace DNA found in tablets and chemistry of falsified, substandard and genuine antimicrobials to determine their characteristic signatures, combined with social network analysis to illuminate their origins and trade routes.
2. What are the public health impacts of poor quality antimicrobials?
What are the impacts of poor quality antimicrobials on patient outcome, global public health, especially antimicrobial resistance?