Extending the PRIDE database ecosystem: PRIDE-Controlled Access (PRIDE-CA) and the PRIDE-Knowledgebase (PRIDE-KB)

Proteomics is the large-scale study of proteins, and reveals a lot about how organisms function in health and disease. The PRIDE database, established in 2004 at the European Bioinformatics Institute (EMBL-EBI), is the world-leading proteomics data repository. It enables researchers to share, study and reuse proteomics data. We aim to extend PRIDE resources by creating controlled-access data capabilities (PRIDE-CA) that will allow clinical sensitive human proteomics data to be held and disseminated securely. PRIDE-CA will enable researchers to share and learn from important clinical studies. We also aim to develop PRIDE Knowledge-Base (PRIDE-KB) as a complementary resource, to store, disseminate and integrate reanalysed datasets, which can generate new biological insights from existing data. In PRIDE-KB, we will initially focus our efforts on proteogenomics data, which combines proteomics and genomics, and is increasingly relevant in clinical studies and personalised medicine approaches.