Expression profiling of African trypanosomes in human and primate hosts: identification of biomarkers for diagnosis, drug target identification and dissection of virulence pathways

Vincent is a molecular parasitologist interested in developing novel and/or improved control strategies for neglected tropical diseases. His Fellowship involves determining the gene expression profile of African trypanosomes - the parasite responsible for sleeping sickness in humans - during various stages of infection in human and non-human primate hosts. The disease evolves through clinically distinct stages, namely early/stage 1 and late/stage 2. Vincent’s work aims to identify and validate biomolecules that can be used in diagnosis and staging of the disease, molecular processes responsible for pathogenesis, and novel drug targets for chemotherapeutic control.

This grant was awarded under the scheme's previous name of Training Fellowships in Public Health and Tropical Medicine.