Exploring new antimicrobial pathways using a combinatorial biosynthetic approach

The aim of Yu Heng's research is to address the problem of antimicrobial resistance by discovering new natural product analogues that can engage previously unexploited antimicrobial targets. These analogues will be generated through combinatorial engineering of biosynthetic pathways, aided by ongoing advances in DNA assembly and sequencing techniques. Yu Heng will undertake the fellowship with Professor Pamela Silver at Harvard Medical School, working in collaboration with Professor Sarah O'Connor at the John Innes Centre, and Professor Peter Greenberg at the University of Washington.