Exploring innate-like and adaptive gamma delta T cell paradigms in health and disease

Background 

Our research is focused on an unusual type of immune cell called 'gamma-delta T-cells'. These are evolutionarily ancient and powerful, capable of recognising and killing infected or cancerous cells. However, it has remained unclear how gamma-delta cells recognise signs of abnormality on target cells, and in which immune scenarios this occurs.

Approach

Our research plan combines different techniques to explore two key subtypes of gamma-delta T cells, and determine the molecular targets they recognise on infected or cancerous cells. We will also assess how they function in different tissues of the body, and how their function changes during disease states.

Expected Impact

The research should revolutionise our understanding of a very important and poorly understood type of immune cell, and will pave the way for scientists to exploit them in new therapies against infection and cancer.