Dissecting the chemokine basis for the orchestration of the in vivo inflammatory response

Professor Graham's research intends to improve our understanding of how an inflammatory chemokine response is coordinated and regulated. Using cutting-edge genome engineering, his lab will generate mice with silenced inflammatory chemokine receptors. This silencing is reversible to allow the receptors to be selectively switched on in turn, as well as in select combinations, illuminating the role of each receptor in the orchestration of the chemokine-dependent inflammatory response. He also aims to determine the dynamics of receptor expression in the orchestration of tissue-specific in vivo inflammatory responses.