Differentiation competence of pluripotent cells

The aim of Sally's work is to understand how pluripotent cells select particular lineages as they exit pluripotency. There is considerable variability between individual cells in the way they respond to differentiation cues, for reasons that are currently not well understood. Sally is exploring the idea that changes in cell adhesion influence the way that cells integrate information from their environment. The hope is that understanding this level of regulation will help to resolve the apparent unpredictability of the differentiation response.