Development of a method for clinical interpretation of cancer genomes

Cancer patients have different outcomes and responses to therapy, indicating that the development of personalised approaches is required. Recent technological advances have facilitated the sequencing of tumour genomes of thousands of cancer patients to identify the mutations that have occurred during tumour development. However the interpretation of these data is challenging and complex.  My proposal will use an innovative computational strategy to personalise the clinical interpretation of patients’ genomes. I will employ this novel approach to investigate how differences in individual patients' tumour genomes are linked to survival in colorectal cancer.