Defining reservoirs and transmission of antimicrobial-resistant Escherichia coli using a One Health approach

Catherine's research will take a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli. This will involve the use of whole-genome sequencing to determine the genetic relatedness of isolates and associated mobile genetic elements from different sources to define shared reservoirs. Mathematical modelling will be used to infer transmission, test hypotheses and to determine the likely impact of interventions to reduce transmission of antimicrobial-resistant E. coli. During her Fellowship, Catherine will work with Professors Sharon Peacock (London School of Hygiene and Tropical Medicine), Julian Parkhill (Wellcome Trust Sanger Institute), and James Wood (University of Cambridge).