Decoding riboregulation in complex cellular behaviour of bacteria

The behaviour of cells is dependent on the expression of genetic information and can be especially important in responses to stress and other environmental signals. In particular, rapid adaptations to constantly changing environments enable bacteria to withstand harmful conditions, to use available resources efficiently, and to launch complex programs during host infection. Regulatory RNA molecules, together with dedicated partner proteins, are often involved in controlling this adaptive process.

We will study regulatory RNA-protein complexes by determining their structures and functions, moving from individual molecules to large flexible assemblies within cells. We will investigate both established model bacteria and pathogenic species, including those that are highly antibiotic-resistant organisms and for which new drugs are urgently needed. Understanding how bacteria employ RNA-protein complexes to control nutrient utilisation and virulence would not only aid the general understanding of cellular adaption to changing environments but could also lead to new antibacterial treatments.