Characterising causal alleles for common disease

Professor McCarthy's research focuses on using large-scale genetic and genomic approaches to understand the genetic variants underlying predisposition to type 2 diabetes and those influencing related phenotypes including obesity and glycaemia. His research seeks also to translate gene identification into biological insights and clinical advances. He will aim to define the mechanisms responsible for the pathogenesis of type 2 diabetes by integrating data emerging from large genetic studies in man with emerging insights from the genomic biology of key tissues and physiological studies in man.