AMADEUS

Professor Geissmann will seek to understand the role that macrophages play in homeostasis, with a particular focus on their role in metabolic diseases such as type 2 diabetes, cardiovascular diseases and inflammatory diseases. The mechanisms underlying the role of macrophages are incompletely understood, in part due to the heterogeneity of macrophages in vivo. One of Professor Geissmann’s aims will be to understand the functional differences between the myb-dependent and myb-independent macrophage lineages, the latter having been described by him in 2012. He will analyse the contribution of these two lineages to inflammation and foam cell formation using mouse models, and undertake genetic analyses of macrophage responses to a lipid-rich diet using Drosophila.