Intellectual property and translation - our approach
This guide summarises our approach to Intellectual Property (IP). It provides advice on what you need to consider when you apply for funding, during your grant and when you commercialise Wellcome-funded IP.
Overview
Research outputs generated by Wellcome-funded science should be translated into practical applications as quickly and effectively as possible.
This is in line with our Constitution [PDF 153KB], which states that when funding research, 'it is expected that a large part of such research may lead to results that will benefit the life, health and well-being of humankind'.
We define research outputs broadly. They include patentable inventions, software, datasets, designs, materials (such as reagents and cell lines) and know-how.
The guidance on this page applies to awards made on our standard grant conditions. It does not apply to:
- awards made to companies
- other legacy schemes or awards which were made on bespoke terms by our Innovations team, usually done in the form of a funding agreement rather than a standard award letter.
What we expect from the researchers and organisations we fund
We expect you to manage your research outputs in a way that will achieve the greatest health benefit, while complying with our grant conditions and the policies we refer to on this page. This might involve:
- translating inventions into new drugs or medical devices which benefit patients directly
- developing and disseminating new research tools, software and materials, to help the research or translational efforts of others.
The methods used to generate impact from research outputs may vary, but the chosen method must be based on an assessment that will lead to the greatest health benefit.
You and your organisation must:
- make their outputs freely available to others (open access), or
- use intellectual property (IP) as a tool to protect and commercialise them.
When we assess grant applications, we look at the steps you've taken to benefit health through your previous research. This is as important to us as your publication history.
Before you apply for funding
All applicants and organisations must read our:
- Grant conditions – section 8 (as well as condition 4.8 'Management of the Grant and reporting' for our annual IP and Commercialisation reporting requirements)
- IP policy
- Consent and revenue and equity sharing policy.
If your research is likely to generate significant research outputs that will be of value to other researchers and users, you must complete the outputs management plan section of your grant application. Learn how to complete an outputs management plan.
Collaborating with others on your research project
If you plan to collaborate with others on your research project, you must make sure that you comply with grant condition 8.1 in relation to the ownership and protection of IP.
The organisation administering your grant is expected to own all Wellcome-funded IP (apart from copyright in research articles which may be owned by the authors). This is important to avoid delaying the delivery of any public health impact. This can happen if various parties can’t agree over the ownership of IP and how the IP in question will be later commercialised. Limited exceptions are allowed under grant condition 8.2, which enables access to proprietary materials and the background IP of others. In these cases, when dealing with others, your organisation must ensure that the funded research project can still deliver the anticipated public health impact. This is not an issue if the award we fund does not generate any IP.
This exception does not apply to ownership of IP by individual inventors because under charity law, public health impact must be prioritised and any private benefit must not be excessive.
If you're using a proprietary research tool provided by a company for other research purposes, you can:
- share research data that you generate using that tool, which relates to the performance of that tool, and
- allow that company to own any incidental improvements to the tool (these are likely to be improvements which happen to be made while using the tool).
All other results and IP generated from use of the tool should be owned by the funded organisation, so that they can be published and/or commercialised in line with Wellcome’s policies.
Collaborators should not be able to veto conditions relating to the commercialisation of Wellcome-funded IP, but there is an expectation that they should be treated fairly, given their contribution to the project. Below are examples of some aspects that we would expect collaborators to agree within a collaboration agreement:
- access to arising datasets (for non-commercial research purposes) by collaborators is fair and reasonable;
- financial returns from any commercialisation (after deduction of our standard 25% revenue share) are distributed in an equitable way between collaborating institutions who contributed to the creation of the IP in question; and
- the lead organisation (as the commercialising party) should discuss the commercialisation plan with collaborators and update them on progress.
Conflicts of interest
You should think about whether you have any conflicts to declare under our Conflicts of interest policy: Wellcome-funded researchers and commercial organisations. This may come up if you have relationships with industry, other (commercially funded) research collaborations or positions as consultants, scientific advisors or directors.
How to identify and protect IP
You should immediately tell your research office/technology transfer office about the creation of any significant research outputs (for example, potentially patentable inventions, new software or new materials such as antibodies or cell lines).
You should work closely with your organisation to determine whether to use IP as a tool to commercialise such outputs, or whether to instead make them freely available through open access.
If a significant research output has been created, and you have determined that the best way to achieve health benefit is by commercialising the IP, you must comply with our:
- Grant conditions (condition 8.3), and
- Consent and revenue and equity sharing policy.
You can use your Wellcome grant to pay for the initial costs of protecting patents and registering designs. After this, your employer is responsible for all additional costs of protecting, maintaining and commercialising that IP throughout its lifetime.
Details of significant research outputs and IP creation must be included in your organisation's annual IP and Commercialisation report to Wellcome. Review the 'Reporting your IP to Wellcome' section for more information.
Getting consent
We want to make it quicker and easier for organisations to translate promising scientific discoveries. In most cases, you no longer need our consent before commercialisation (this is our ‘consent waiver’). This applies to grants awarded under our standard grant conditions, unless your award letter/funding agreement state otherwise.
Before you enter into any commercialisation agreement, you should check the specific terms under which Wellcome funded the project. This will help you determine if you need to get our written consent first.
We can also withdraw this consent waiver under our standard grant conditions if an organisation fails to meet our requirements. We check this each year when we review each organisation's annual IP and Commercialisation report. If we withdraw the waiver, all future IP transactions by that organisation will need our written consent beforehand, until we feel comfortable enough with their activities to reintroduce the waiver.
Transactions
Any IP transactions, such as licences, options, assignments, material transfer or evaluation agreements, must be consistent with our guidance on commercialisation agreements. The driving factor when negotiating these agreements should be maximising public benefit to achieve the maximum health impact, not generating revenue.
Wellcome expects a heavy focus on equitable access to ensure the maximum health impact is achieved. We expect organisations to include provisions in commercialisation agreements for equitable access for low- and middle-income countries where appropriate. The GHIAA MAPGuide may be a good starting point for institutions to review various equitable access clauses and strategies that may be suitable for them to use. Working with patent pools (such as the Medicines Patent Pool) to licence Wellcome-funded IP can be an effective way to facilitate equitable access.
All new transactions related to Wellcome-funded IP must be included in your organisation's annual IP and Commercialisation report. Review the 'Reporting your IP to Wellcome' section for more information.
Our revenue and equity share
We have a legal obligation to make sure that our funding is used for charitable purposes – not to financially benefit individuals or companies. So, in most cases, we apply a flat rate of 25% revenue and equity share where outputs of our standard grants are commercialised.
Our equity share is typically held by the relevant organisation on trust for us, and then treated as revenue when the organisation sells our shares along with its own.
Revenue that organisations have kept to date:

Revenue kept by organisations per year has ranged from a total of around £500,000 to nearly £2.7 million. The number of organisations which applied to keep Wellcome’s share of revenue has increased over time, from 8 in 2019 to 13 in 2025.
Wellcome
Types of report received:

In 2025 we achieved 94% compliance overall of reports submitted. 12 of the 13 organisations which applied to keep Wellcome’s share of revenue were successful, and between them they kept nearly £0.8 million. 9 other organisations returned Wellcome’s share (see ‘Applying to keep your share of Wellcome’s revenue (revenue retention)’). 26 other organisations did not generate any revenue but reported other IP- or commercialisation-related activities such as new transactions.
Wellcome
In the 2025 reporting cycle, we learned of:
- 87 new transactions (IP assignments, licences) including
- 17 new equity transactions (spin-outs)
- 143 invention disclosures
- 174 patent applications
- 218 granted patents
- 36 activities relating to other IP
Reporting your IP to Wellcome
Your organisation is responsible for reporting IP creation and its subsequent sharing (open access) or its commercialisation to Wellcome (Grant Condition 4.8). We expect you to work with your organisation to support this by keeping them updated on the creation of significant research outputs and how you plan to use them.
IP and Commercialisation report
Your organisation must complete and submit an IP and Commercialisation report by the end of February each year. This includes providing unredacted copies of commercialisation agreements that you have entered into, which relate to the activity set out in your report. This is a condition of our funding and maintains your organisation's consent waiver (see Grant Condition 8.3(b)).
Each November, we will invite each organisation to complete the report. If your organisation has not received this invitation by 1 December, contact IPCommercialisation@wellcome.org.
Guidance on how to complete the electronic form is available in our IP and Commercialisation Quick Start Guide.
The report:
- should cover all IP-related activity for the previous calendar year and must include Wellcome grant numbers, where known
- must include copies of the commercialisation agreements relevant to all IP-related activity
- must be submitted, even if you’re only saying there hasn’t been any IP-related activity.
It is your organisation’s responsibility to ensure that all information contained in the report is accurate to the best of its knowledge.
If your organisation does not provide full copies of agreements, it's consent waiver will be revoked. You will need to get our written consent to each proposed transaction before it can be finalised. This will likely lead to contracting delays.
Overseas organisations are responsible for ensuring they account for any relevant taxes in country in which their organisation is based and should seek independent specialist advice if necessary. Wellcome is not responsible for any such taxes.
General feedback to submitting organisations
This feedback is based on previous reports.
Well-drafted clauses include:
- clearly carving out which party owns IP and improvements where multiple parties are contributing their IP for the purposes of commercialisation;
- in most cases, clear definitions of terms such as ‘commercially reasonable efforts’;
- including low- and middle-income countries (LMICs) within the development milestones in order to ensure that the healthcare products in question are made available in those territories at an affordable price within an appropriate timeframe;
- setting out the circumstances in which IP would be abandoned or revert to the licensor (to avoid licensees sitting on an exclusive licence where they are not doing anything with it);
- clear consequences where there are disagreements around commercialisation, such as expert review. Development of the IP should be a priority to ensure the maximum health impact is achieved. The use of independent experts to make diligence requirements more enforceable is encouraged;
- allowing the field to be carved up in an exclusive, field restricted licence. If the licensor sees an opportunity to use the licensed IP to develop products in the field that the existing licensee does not wish to explore, then the organisation could license the IP to another party. This helps maximise the health impact of the IP rather than it sitting exclusively with one party whose plan to commercialise it is more limited.
Wellcome expects a heavy focus on equitable access to ensure the maximum public health benefit is achieved.
Whilst we have seen some engagement with this issue in commercialisation agreements, a much stronger focus on equitable access is required overall.
Clauses which provide for the outputs of a grant to be made available to LMICs in accordance with Wellcome's equitable access statement are preferable. This includes having an appropriate global access plan in place and ensuring that any economic barriers in place were low. We have also seen specific reference to meeting Wellcome’s objectives and an organisation's access statement. The organisation's access statement contained examples of how it would develop creative licensing strategies to prioritise affordable access. This goes a step further to help ensure access commitments can be achieved.
Other mechanisms we have seen work in the past are:
- guaranteed supply volumes or price caps in certain territories;
- priority access to products for countries involved in research or clinical trials;
- use of commercially reasonable or best efforts to keep barriers to access as economically low as possible whilst remaining sustainable for the licensee;
- clear consequences of what happens if the IP in question is not made available as the equitable access clause provides within a set timeframe (for example, 3‐5 years as appropriate for the technology in question). For example, see Step-in rights.
We appreciate that this can be a challenging topic to address with licensees, but where the technology in question could be useful in LMICs, organisations must ensure that it is not just patients in the developed world that will benefit.
Refer to the GHIAA MAPGuide for useful guidance notes and to see examples of various provisions & strategies that may be suitable for use in an organisation's licences.
Wellcome will monitor this area closely in future cycles with a view to seeing an improvement. Failure to address equitable access (and instead focussing solely on maximising financial return) is the most likely reason for us to remove an organisation's consent waiver in future.
Our goal is to ensure that the Wellcome funded IP in question leads to a public health benefit without significant delays. Therefore, Wellcome‐funded IP must not be maintained solely as a barrier to the research, development and commercialisation activities of others. Some agreements have not contained provisions to address what happens if commercialisation is held up.
For example, you should have the necessary reversion rights to commercialise (in the context of exclusive licences) if the licensee doesn’t do so, within a reasonable time for that IP. Refer to Wellcome’s step-in rights for more information, as referred to in our standard grant conditions.
We would first expect you to reclaim the IP (for example, by the exclusive licence terminating or becoming non‐exclusive) if it wasn’t being actively developed by your licensee. Ensure you preserve your rights to do this.
In the agreements with spin‐outs that we’ve seen previously, it was not always clear that it was a spin‐out. This should ideally be made clear at the outset of the agreement. Diligent efforts clauses with spin-outs were also weak ‐ we would expect the same diligence requirements should apply to a spin‐out as they would to any other third party licensee.
A stronger focus on future health impact is also required and better use of objective obligations. For example, what does the spin‐out need to achieve in terms of technology development and/or moving the product towards market? And when does this need to happen in order to retain control of the IP?
- Recitals: We recommend inserting brief recitals with some background on the agreement to provide context.
- Termination: Ensure IP agreements include basic boilerplate provisions such as termination clauses.
Each report enables us to assess whether the terms are reasonable and in accordance with our policies and guidance. This is difficult if you:
a) do not supply agreements on the basis that they are confidential, or
b) redact key sections of the agreement. The annual survey contains confidentiality provisions, which you can share an extract of, with your licensees, if necessary.
Some organisations are inserting provisions in their licences to inform licensees that their funder(s) will review licences, sometimes specifically naming Wellcome. We would encourage all licences to include this in any transactions relating to Wellcome‐funded IP. For example: The Licensor may disclose Confidential Information of the Licensee to any Third Party:
(i) to whom the Licensor is, at the Effective Date, under a legal or contractual obligation to disclose such information, or
(ii) who was involved in the development of the Licensed Intellectual Property Rights/Licensed Products/Services [as defined in the agreement] including the creation, invention or funding of the Licensed Intellectual Property Rights/Licensed Products/Services.
Applying to keep your share of Wellcome’s revenue (revenue retention)
Organisations can only apply to keep Wellcome’s share of revenue received in the year covered by the report (we call this revenue retention). If your organisation wants to do this, it must:
- include a 'revenue retention request' in the report
- submit the form to Wellcome by the February deadline. Reports submitted after this date may result in your organisation's request being refused.
We are keen for organisations to keep up our share of revenue that they generate. This is, except under limited circumstances, limited to a maximum of £1 million per year (excl. VAT) per organisation. If your organisation’s application to keep our revenue is successful, the money being kept can be spent on projects that support translation. We also encourage organisations to describe how the amount being kept will be matched from other sources, to maximise the potential benefits. The projects do not need to be linked to Wellcome-funded awards if they align with Wellcome’s health challenge areas (mental health, infectious disease and climate and health). If they align with our discovery research programme they should focus on advancing Wellcome-funded awards or any translational activity. Consideration will also be given to projects that facilitate equitable access, particularly in low- or middle-income countries.
Tips for your organisation's application
Your organisation should:
- provide as much detail as possible about the proposed use of the money it wants to keep
- notify us of any changes to the proposed use after a successful application, before you re-allocate funds
Wellcome may reject an application if your organisation has misspent funds in a previous cycle.
Your organisation must complete Appendix 2 of the report – Our Revenue and Equity Sharing Agreement – if they entered into one or more commercialisation agreements related to Wellcome-funded IP in the year covered by the report.
Revenue kept can be added to an institutional fund for IP and patent costs but should not replace or substitute the core funds available at that organisation.
Wellcome’s IP and revenue sharing policies will not typically apply to activities funded indirectly through revenue kept, but we can still request that our conditions flow down in certain circumstances (for example, depending on the value retained and the proposed work).
If your organisation is expecting large revenue amounts, especially relative to its history of translational activities, please let us know as soon as possible, before submitting a request to keep our share of revenue. This will help shape your application to keep the revenue and reduce the risk of it being unsuccessful.
Early discussion of unusually large transactions may allow us to consider whether you need an extended spend period. Revenue kept must usually be at least committed within one year of the request being approved. Organisations are informed about the outcome of their requests annually around June. A spend report is then due at the end of the following reporting period in December. In practice, this results in around 18 months to spend any revenue kept. Wellcome will notify organisations when spend reports are due.
We may grant a longer spend period in exceptional circumstances, at our discretion. We reserve the right to:
- enforce limits on amounts kept and spend periods – for example, if we have concerns about an organisation’s ability to use the revenues effectively, and
- reject exceptionally large amounts (this will depend on what is unusually large for the organisation in question, based on their history of translational activity)
Individual transactions below £10,000 relating to material transfers do not need to be reported. Revenue kept in this category should still be used to support translational activity. We can still review or audit the use of these amounts.
Individual transactions below £10,000 relating to anything else should be reported as usual.
Check your contact details are up-to-date
Ensure your organisation’s contact details are up-to-date so you can receive your invite to complete the report. You can add more than one contact email address.
If you do not keep these updated, you may not receive the invite to the report. If we do not receive a response after following up, this could result in your organisation’s consent waiver being revoked and your organisation’s missing the opportunity to keep Wellcome’s revenue share.
Check your contact details are up-to-date
Ensure your institution’s contact details are up-to-date so you can receive the bespoke link for the next reporting cycle. You can add more than one contact email address.
If you do not keep these updated, we may end up sending the link to an inactive email address. If we do not receive a response after following up, this could result in your institution’s consent waiver ultimately being revoked and your institution missing the opportunity to retain Wellcome’s revenue share.
Legacy awards agreed with our Innovations team
Where our Innovations team funded Research and Development projects – through either a bespoke funding agreement or a convertible loan (rather than on Wellcome’s standard grant conditions) – the specific provisions negotiated for that project will apply.
The protection and management of Wellcome-funded IP may be overseen by an IP management group and Wellcome’s prior consent to the commercialisation may be required. The revenue share may be different to the default 25%, but your organisation can still apply to keep it in line with the guidance set out on this page.
Contact us
Contact Funding Information Desk about:
- how to complete your grant application, including questions on outputs management plans
- how to comply with our IP policy.
Contact our IP Commercialisation inbox about:
- getting a customised link to the electronic consolidated IP and commercialisation report form
- how to complete and submit your IP report
- how to calculate revenue/equity share
Related content
- Conflicts of interest policy: Wellcome-funded researchers and commercial organisations
- Consent and revenue and equity sharing policy
- Intellectual property and translation - our approach
- Intellectual property commercialisation agreements - guidance
- Intellectual property guidance
- Intellectual property policy