Stimulating systemic regional uptake of principles of good RCTs in Low and Middle Income Countries

Generating robust and reliable evidence from good randomised controlled trials (RCTs) is a critical component of good healthcare across the world. The Good Clinical Trials Collaborative’s Guidance for Good Randomized Clinical Trials describes five principles that lead to reliably informative, ethical and efficient trials. This proposal brings together four research networks, based in Latin America, Singapore, South Africa, and Southeast Asia, to support locally-led uptake of the guidance and its principles in low- and middle-income countries (LMICs). By investing in and collaborating directly with these networks the Collaborative will enable and promote content development decision-making to be taken at the most relevant local level to design and direct appropriate learning opportunities for achieving sustainable change. Project goal: Strengthen the capability of individuals, institutions and systems to produce reliable evidence through RCTs that enables informed changes in healthcare practice. Project outcomes: high-quality, context appropriate, learning materials designed to improve the capabilities and competencies of key implementers and national/regional bodies that fund and regulate RCTs in LMICs, and stronger regional and national networks in LMICs that play a key role in the decision-making and implementation of clinical trials.