Integration of kinases with membrane trafficking machinery

All living cells are surrounded by cell membranes. These are essential to keep the inside of the cell separate from its outside surroundings, but are also very dynamic, controlled structures to make sure that the cell remains healthy and functioning within its outside environment. Problems in the functioning of cell membranes can result in disease. It is therefore important to understand the complex processes which control cell membrane structure and function.

I am studying the process of 'endocytosis' - an important way for cell membranes to transport materials from outside to inside. My research is focused on a group of proteins called 'NAKs'. Using cells grown in dishes, I will measure the exact mechanisms of NAKs to control endocytosis. NAK proteins may also have a role in some diseases of the nervous system, and so my research will inform efforts to discover and develop new treatments targeting NAKs.