Centres for Antimicrobial Optimisation Network – Uganda (CAMO-Net Uganda)

CAMO-NET aims to address the global impact of antimicrobial resistance (AMR) on human health via optimised antimicrobial use by establishing a sustainable global research ecosystem developed across HICs and LMICs. The CAMO-NET Uganda application is led by the Infectious Diseases Institute Makerere University (IDI) and comprises three research projects: (1) Investigating the patterns and trends in antibiotic prescribing among people living with HIV (PLHIV) enrolled in routine cohorts at IDI Clinics. This project will include qualitative studies and cohort analyses to improve understanding of antibiotic prescribing in an LMIC HIV clinic. (2) Innovative approaches to optimize antibiotic therapy for patients with multimorbidity in an outpatient HIV clinic in Uganda. This project will develop a multidisciplinary clinical platform for optimizing antibiotic use in the context of multimorbidity among PLHIV, validate population pharmacokinetic-pharmacodynamic models for selected antibiotics and evaluate innovative point of care therapeutic drug monitoring and its adoption for selected antimicrobials in PLHIV. (3) Understanding trends in antibiotic consumption and use among patients attending six regional referral hospitals in Uganda to inform and evaluate pharmacy staff-led interventions. Additionally, IDI will serve as capacity-building lead, providing a platform for collaborative and capacity-strengthening activities for CAMO-NET consortium partners.