Focussing on biomedical discovery in the North-East of England: A high-throughput/high-content live imaging system for cells, tissues and small model organisms

Imaging (HCI) at the University of Leeds. HCI of cells is used in biological research and drug discovery to assess specific characteristics or behaviours (“phenotypes”) of cultured cells. Microscopical imaging measures visual features such as cell shape, cellular organization, the location of specific proteins within the cells, or the changes in these features over time. This equipment will hugely automate the analysis of these visual features in components of cells, whole cells, complex tissues (“spheroids” and “organoids”), patient-derived clinical specimens and even small animal models of human disease. The research enables rapid and opportunistic discovery science in an exciting range of basic biomedical research, as well as translational research for patient benefit, using a system that is affordable, exceptionally versatile and easy-to-use. The popularity of HCI means that the equipment will be used at full capacity.