Demonstrating impact of mosquito-assisted larviciding (autodissemination) as a complementary malaria intervention in rural Tanzania

Effective malaria control and eventual elimination requires new complementary vector control tools that address gaps associated with current insecticidal bednets and indoor residual spray. These existing tools mainly target indoor-biting mosquitoes, and are increasingly affected by insecticide resistance. One of the most promising options for controlling mosquitoes outdoors is use of chemicals that target larval mosquitoes in their aquatic habitats. The autodissemination strategies uses mosquitoes to spread chemicals to their own larval habitats, that achieving high habitat coverage with little human labor or need for compliance. I propose to "demonstrate the impact of autodissemination with pyriproxyfen as a complementary malaria intervention in rural Tanzania". Pyriproxyfen works by preventing mosquito pupae from developing into adults and sterilizing adult mosquitoes. Expected outcomes include optimization of intervention delivery, demonstration that it can reduce malaria vector densities, Results will inform future large scale-trails to measure the epidemiological impact of autodissemination on malaria incidence.